周吉照 王静
[摘要] 意图 讨论乳癌彻底治愈术后放化疗对乳腺癌中晚期患者T淋巴细胞及生存率的影响。 办法 挑选本科2010年6月～2011年12月收治的乳腺癌中晚期患者56例，医治计划为手术+放疗+化疗，手术方法为乳癌彻底治愈术。术后进行化疗别离于第1、8天给予多西紫杉醇75 mg/m2静脉滴注，缓慢滴注时刻为3 h；术后第1～3天给予顺铂溶于生理盐水250 ml静脉滴注，剂量20 mg/m2，时刻1 h，3周为1个周期；三维适形放疗为DT 2 Gy/次，1次/d，5次/周，调查患者医治前后相关免疫目标的改变及生存率。 成果 患者医治后的CD3、CD4、CD8、CD4/CD8及NK较医治前均下降，差异有统计学含义（P<0.05）。乳癌彻底治愈术56例，乳癌改进彻底治愈术占33.93%（19/56）。术后随访1年局控率到达75.0%（42/56），1年生存率到达80.36%（45/56），2年局控率到达21.43%（12/56），2年生存率到达26.78%（15/56），临床总有功率为76.78%（43/56）。 定论 乳腺癌中晚期患者乳癌彻底治愈术后放化疗对机体免疫力可形成必定的影响，医治中应考虑其不良反应，针对性地采纳相应医治计划，以进步临床效果。
[关键词] 乳腺癌中晚期；乳癌彻底治愈术；放疗；化疗
[中图分类号] R737.9 [文献标识码] A [文章编号] 1674-4721（2014）04（a）-0031-03
[Abstract] Objective To investigate the impact of radiotherapy and chemotherapy after radical operation of breast cancer on T lymphocyte and survival rate in patient with advanced breast cancer. Methods 56 patients with advanced breast cancer in our department from June 2010 to December 2011 were selected，treatment option was surgery+radiotherapy+chemotherapy，operation mode was radical operation of breast cancer.Postoperative chemotherapy was given in the first 1，8 days docetaxel 75 mg/m2 intravenously，slow infusion time was 3 hours，1 to 3 days after cisplatin dissolved in 250 ml of saline infusion，the dose 20 mg/m2 infusion time 1 hour，3 weeks for 1 cycle.Three-dimensional conformal radiotherapywas DT 2 Gy/time，1 time/day，5 times/week，before and after treatment related immune system indicator and survival rate was observed respectively. Results CD3，CD4，CD8，CD4/CD8 and NK after treatment was lower than before treatment respectively，with statistical difference（P<0.05）.56 cases of radical operation of breast cancer，modified radical mastectomy for breast cancer accounted for 33.93%（19/56）.Patients were followed up for 1-year local control rate was 75.0%（42/56），1-year survival rate was 80.36%（45/56），2-year local control rate was 21.43%（12/56），2-year survival rate was 26.78%（15/56），the total clinical efficiency rate was 76.78%（43/56）. Conclusion Patients with advanced breast cancer after radical radiotherapy and chemotherapy for breast cancer immunity have been affected，clinical adverse reaction should be considered in this regard，take the appropriate treatment program targeted in order to improve clinical effect.
[Key words] Advanced breast cancer；Radical operation of breast cancer；Radiotherapy；Chemotherapy
我国乳腺癌发病率现在呈上升趋势，占女人新发恶性肿瘤的30%，成为女人最常见的恶性肿瘤之一[1]。跟着分子生物学技能及治疗规范化水平的不断进步，乳腺癌的发病率尽管整体呈升高状况，但据统计死亡率呈不断下降趋势。本研讨旨在讨论患者乳癌彻底治愈术后放化疗对机体免疫力及生存率的影响。
