赵璐
[摘要] 意图 为了探求抗青光眼药物的运用关于青光眼患者泪液MUC5AC含量及眼表改动的实践影响，从而为青光眼的临床医治供给学习和根据。 办法 本次研讨选取我院2009年12月～2010年12月期间收治并施行药物医治的青光眼患者48例（48眼）为青光眼患者组，一起选取同期体检的无青光眼的健康人群48例为健康对照组。调查并比较两组人群的泪液MUC5AC含量以及眼表功用评分成果。 成果 （1）健康对照组研讨目标的MUC5AC含量显着高于青光眼患者组施行医治3个月以及6个月后的水平，且组间数据比较差异具有显着的统计学含义（t=2.4519，P=0.0161；t=3.7697，P=0.0003）；青光眼患者医治6个月后的MUC5AC含量显着低于医治3个月后的水平，且数据差异具有显着的统计学含义（t=2.1543，P=0.0338）；（2）健康对照组研讨目标的眼表功用评分成果显着低于青光眼患者组施行医治3个月以及6个月后的水平，且组间数据比较差异具有显着的统计学含义（z=-7.013，P=0.000；z=-8.485，P=0.000）；青光眼患者医治6个月后的眼表功用评分显着高于医治3个月后的水平，且数据差异具有显着的统计学含义（z=-3.578，P=0.000）。 定论 长时刻的抗青光眼药物医治可导致患者的泪液MUC5AC削减及眼表危害，而且跟着药物医治时刻的延伸，危害也不断加重。
[关键词] 抗青光眼药物；泪液MUC5AC；眼表改动
[中图分类号] R775 [文献标识码] B [文章编号] 1673-9701（2014）32-0124-02
Study on the effects of MUC5AC content and tear and ocular surface changes of anti-glaucoma drugs
ZHAO Lu
Department of Ophthalmology， Luohu Hospital of Shenzhen City， Shenzhen 518000，China
[Abstract] Objective In order to explore the practice effect of the MUC5AC content of tear and ocular surface changes of the glaucoma patient who used anti-glaucoma drug treatment， to provide reference and basis for the clinical treatment of glaucoma. Methods Selected 48 patients with glaucoma who received the implementation of drug treatment in our hospital from December 2009 to December 2010 as glaucoma group， and selected 48 healthy people as healthy control group at the same time. Evaluation results were compared between the two groups in tear MUC5AC content and ocular surface function. Results （1） MUC5AC in control group was significantly higher than that of healthy subjects with glaucoma group three or six months after treatment， with significant statistical significance between group differences and data （t=2.4519， P=0.0161； t=3.7697， P=0.0003）； The content of MUC5AC in glaucoma patients after treatment was significantly lower than that of three or six months after treatment， a statistically significant difference （t=2.1543， P=0.0338）； （2）Healthy ocular surface function group study score was significantly lower than in patients with glaucoma group treatment three or six months after treatment， with significant statistical significance between group data and compared the difference （z=-7.013，P=0.000；z=-8.485，P=0.000）； Ocular surface function in patients with glaucoma treatment six years later， the scores were significantly higher than the scores three months after treatment， the difference was statistically significant（z=-3.578，P=0.000）. Conclusion Anti-glaucoma medication for a long time can lead to the decrease of tear MUC5AC and the damage of ocular surface，and the bad situation will get worse while the drug treatment prolonged.endprint
